from PyQt4.QtGui import *
from PyQt4.QtCore import *
class ExtendedQLabel(QLabel):
    def __init(self, parent):
        Label.__init__(self, parent)
    def mouseReleaseEvent(self, ev):
        self.emit(SIGNAL('clicked()'))
# Часть скрипта с созданием кнопки
self.button[key] = ExtendedQLabel(self)
self.button[key].setMaximumSize(150,150)
self.button[key].setPixmap(QPixmap(item[key].img))
self.connect(self.button[key], SIGNAL('clicked()'), functools.partial(use, [key,self.nameMenu]))

from PyQt4.QtGui import *
from PyQt4.QtCore import *
import imageop, sys, os, random, codecs, functools, sip,time
# Делает возможным создавить imagebutton
class ExtendedQLabel(QLabel):
    def __init(self, parent):
        QLabel.__init__(self, parent)
    def mouseReleaseEvent(self, ev):
        self.emit(SIGNAL('clicked()'))
class MainUI(QWidget):
    BUTTON_IMAGE = 'button1.png'
    def __init__(self, *args):
        apply(QWidget.__init__,(self, ) + args)
        QWidget.__init__(self)
        self.resize(300, 100)
        self.label = QLabel()
        self.initButton()
    def initButton(self):
        self.label.setText('Button')
        self.ImageButton = ExtendedQLabel(self)
        self.ImageButton.move(0,0)
        self.ImageButton.setPixmap(QPixmap(self.BUTTON_IMAGE))
        self.ImageButton.connect(self.ImageButton, SIGNAL('clicked()'), self.buttonClicked)
     
    def buttonClicked(self):
        self.ImageButton.setPixmap(QPixmap('button2.png'))
        QApplication.processEvents()
        time.sleep(0.3)
        self.ImageButton.setPixmap(QPixmap('button1.png'))
        print('Button Clicked')
if __name__ == '__main__':
    app = QApplication(sys.argv)
    win = MainUI()
    win.show()
    app.exec_()
    sys.exit()

import time
from PyQt4 import QtCore, QtGui
 
class ImageButton(QtGui.QPushButton):
    def __init__(self, parent=None, *args, **kwargs):
        super(ImageButton, self).__init__(parent, *args, **kwargs)
        self._change_image('image1.png')
        self.clicked.connect(self._on_click)
     
    def _on_click(self):
        self._change_image('image2.png')
        QtCore.QTimer.singleShot(300, lambda : self._change_image('image1.png'))
        
    def _change_image(self, path):
        self.setStyleSheet('''background-image: url("%s");
                              background-repeat:no-repeat;''' % path)
 
app = QtGui.QApplication([])
widget = ImageButton("test")
widget.show()
app.exec_()

def __init__(self, parent=None, *args, **kwargs):
        super(ImageButton, self).__init__(parent, *args, **kwargs)

widget = ImageButton("test")

from PyQt4 import QtCore, QtGui
 
class ImageButton(QtGui.QAbstractButton):
    def __init__(self, image1, image2, parent=None, *args, **kwargs):
        super(ImageButton, self).__init__(parent, *args, **kwargs)
        self._pixmap1 = QtGui.QPixmap(image1)
        self._pixmap2 = QtGui.QPixmap(image2)
        self._pixmap = self._pixmap1
        self.clicked.connect(self._on_click)
     
    def _on_click(self):
        self.set_pixmap(self._pixmap2)
        QtCore.QTimer.singleShot(300, lambda : self.set_pixmap(self._pixmap1))
        
    def paintEvent(self, event):
        painter = QtGui.QPainter(self)
        painter.drawPixmap(event.rect(), self._pixmap)
        painter.drawText(self.rect(), QtCore.Qt.AlignCenter, self.text());
                
    def set_pixmap(self, pixmap):
        self._pixmap = pixmap
        self.update()
        
    def sizeHint(self):
        return self._pixmap.size()
 
 
app = QtGui.QApplication([])
widget = ImageButton("image1.png", "image2.png", text="test")
widget.show()
app.exec_()

button = QtGui.QPushButton(clicked=on_click, text='My button', checkable=True)

painter.drawPixmap(self.rect(), self._pixmap)

button.setMaximumSize(width, height)