server.sendmail(fromaddr, toaddrs, msg)
  File "C:\Python25\lib\smtplib.py", line 695, in sendmail
    raise SMTPRecipientsRefused(senderrs)
SMTPRecipientsRefused: {}

#!/usr/local/bin/python


import smtplib

def prompt(prompt):
    return raw_input(prompt).strip()

fromaddr = prompt("testmail@DOMEN.ru")
toaddrs  = prompt("testmail@DOMEN.ru").split()
print "Enter message, end with ^D (Unix) or ^Z (Windows):"

# Add the From: and To: headers at the start!
msg = ("From: %s\r\nTo: %s\r\n\r\n"
       % (fromaddr, ", ".join(toaddrs)))
while 1:
    try:
        line = raw_input()
    except EOFError:
        break
    if not line:
        break
    msg = msg + line

print "Message length is " + repr(len(msg))

server = smtplib.SMTP('name_server@DOMEN.ru')
server.set_debuglevel(1)
server.sendmail(fromaddr, toaddrs, msg)
server.quit()

server = smtplib.SMTP('localhost')
server.set_debuglevel(1)
server.sendmail(fromaddr, toaddrs, msg)
server.quit()

# -*- coding: cp1251 -*-
import smtplib
from email.MIMEText import MIMEText

# отправитель
me = 'sob@yandex.ua'
# получатель
you = 'sob@yandex.ua'
# текст письма
text = 'Это тестовое письмо!\nС наилучшими пожеланиями!\nСаня Кривенко'
#text = unicode(text, "cp1251").encode("koi8-r")
# заголовок письма
subj = 'Привет от Python'

# параметры SMTP-сервера
server = "213.180.204.38" # "smtp.yandex.ua"
port = 25
user_name = "sob"
user_passwd = "******"

# формирование сообщения
msg = MIMEText(text, "", "cp1251")
msg['Subject'] = subj
msg['From'] = me
msg['To'] = you

# отправка
s = smtplib.SMTP(server, port)
s.starttls()
s.login(user_name, user_passwd)
s.sendmail(me, you, msg.as_string())
s.quit()